Genome-Wide Analysis of Disordered Eating Behavior in the Mexican Population.

ABSTRACT: Alterations in eating behavior characterized eating disorders (ED). The genetic factors shared between ED diagnoses have been underexplored. The present study performed a genome-wide association study in individuals with disordered eating behaviors in the Mexican population, blood methylation quantitative trait loci (blood-meQTL), summary data-based Mendelian randomization (SMR) analysis, and in silico function prediction by different algorithms. The analysis included a total of 1803 individuals. We performed a genome-wide association study and blood-meQTL analysis by logistic and linear regression. In addition, we analyzed in silico functional variant prediction, phenome-wide, and multi-tissue expression quantitative trait loci. The genome-wide association study identified 44 single-nucle

SUBMITTER: Martinez-Magana JJ 

PROVIDER: S-EPMC8778304 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature