HERV-K and HERV-H Env Proteins Induce a Humoral Response in Prostate Cancer Patients.

ABSTRACT: A higher expression of human endogenous retroviruses (HERVs) has been associated with several malignancies, including prostate cancer, implying a possible use as a diagnostic or prognostic cancer biomarker. For this reason, we examined the humoral response against different epitopes obtained from the envelope protein of HERV-K (HERV-K env-su_19-37, HERV-K env-su_109-126), HERV-H (HERV-H env-su_229-241, HERV-H env_387-399) and HERV-W (HERV-W env-su_93-108, HERV-W env-su_248-262) in the plasma of patients affected by prostate cancer (PCa), and compared to that of benign prostate hyperplasia (BPH) and a borderline group of patients with atypical small acinar proliferation (ASAP) and prostate intraepithelial neoplasia (PIN) and health

SUBMITTER: Manca MA 

PROVIDER: S-EPMC8778306 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature