Identifying Candidate Protein Markers of Acute Kidney Injury in Acute Decompensated Heart Failure.

ABSTRACT: One-quarter of patients with acute decompensated heart failure (ADHF) experience acute kidney injury (AKI)-an abrupt reduction or loss of kidney function associated with increased long-term mortality. There is a critical need to identify early and real-time markers of AKI in ADHF; however, to date, no protein biomarkers have exhibited sufficient diagnostic or prognostic performance for widespread clinical uptake. We aimed to identify novel protein biomarkers of AKI associated with ADHF by quantifying changes in protein abundance in the kidneys that occur during ADHF development and recovery in an ovine model. Relative quantitative protein profiling was performed using sequential window acquisition of all theoretical fragment ion spectra-mass spectrometry (SWATH-MS) in kidney cortices from

SUBMITTER: Templeton EM 

PROVIDER: S-EPMC8778509 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature