N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers.

ABSTRACT: Transdermal drug delivery is an attractive non-invasive method offering numerous advantages over the conventional routes of administration. The main obstacle to drug transport is, however, the powerful skin barrier that needs to be modulated, for example, by transdermal permeation enhancers. Unfortunately, there are still only a few enhancers showing optimum properties including low toxicity and reversibility of enhancing effects. For this reason, we investigated a series of new N-alkylmorpholines with various side chains as potential enhancers in an in vitro permeation study, using three model permeants (theophylline, indomethacin, diclofenac). Moreover, electrical impedance, transepidermal water loss, cellular toxicity and infrared spectroscopy measurements were applied to assess

SUBMITTER: Dvorakova K 

PROVIDER: S-EPMC8778526 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature