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Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium Saccharomonospora sp.

ABSTRACT: Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ-490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7-chloro-4(1H)-quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti-quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

SUBMITTER: Kim S 

PROVIDER: S-EPMC8778701 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium <i>Saccharomonospora</i> sp.

Kim Sohee S   Le Tu Cam TC   Han Sang-Ah SA   Hillman Prima F PF   Hong Ahreum A   Hwang Sunghoon S   Du Young Eun YE   Kim Hiyoung H   Oh Dong-Chan DC   Cha Sun-Shin SS   Lee Jihye J   Nam Sang-Jip SJ   Fenical William W  

Marine drugs 20211229 1

Analysis of the chemical components from the culture broth of the marine bacterium <i>Saccharomonospora</i> sp. CNQ-490 has yielded three novel compounds: saccharobisindole (<b>1</b>), neoasterric methyl ester (<b>2</b>), and 7-chloro-4(<i>1H</i>)-quinolone (<b>3</b>), in addition to acremonidine E (<b>4</b>), pinselin (<b>5</b>), penicitrinon A (<b>6</b>), and penicitrinon E (<b>7</b>). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear  ...[more]

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