Actinoporin-like Proteins Are Widely Distributed in the Phylum Porifera.

ABSTRACT: Actinoporins are proteinaceous toxins known for their ability to bind to and create pores in cellular membranes. This quality has generated interest in their potential use as new tools, such as therapeutic immunotoxins. Isolated historically from sea anemones, genes encoding for similar actinoporin-like proteins have since been found in a small number of other animal phyla. Sequencing and de novo assembly of Irish Haliclona transcriptomes indicated that sponges also possess similar genes. An exhaustive analysis of publicly available sequencing data from other sponges showed that this is a potentially widespread feature of the Porifera. While many sponge proteins possess a sequence similarity of 27.70-59.06% to actinoporins, they show consistency in predicted structure. One ge

SUBMITTER: Sandoval K 

PROVIDER: S-EPMC8778704 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature