Evaluation of Transplacental Antibody Transfer in SARS-CoV-2-Immunized Pregnant Women.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy could result in adverse perinatal outcome. Clinical data on the assessment of the immune response in vaccinated pregnant women and subsequent transplacental antibody transfer are quite limited.

Objective

To assess maternal and neonatal neutralizing antibody levels against both wildtype and Delta (B.1.617.2) variants after maternal mRNA vaccination.

Study design

This cohort study was conducted 29 pregnant women who were vaccinated at least one dose of Moderna (mRNA-1273) vaccine. Both neutralizing antibody (wildtype and Delta variant) and S1 receptor binding domain IgG antibody levels were evaluated in maternal and cord blood on the day of delivery.

Results

Superio

SUBMITTER: Shen CJ 

PROVIDER: S-EPMC8778956 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature