Feline and Canine Cutaneous Lymphocytosis: Reactive Process or Indolent Neoplastic Disease?

ABSTRACT: Cutaneous lymphocytosis (CL) is an uncommon and controversial lymphoproliferative disorder described in dogs and cats. CL is generally characterized by a heterogeneous clinical presentation and histological features that may overlap with epitheliotropic lymphoma. Therefore, its neoplastic or reactive nature is still debated. Here, we describe clinicopathological, immunohistochemical, and clonality features of a retrospective case series of 19 cats and 10 dogs with lesions histologically compatible with CL. In both species, alopecia, erythema, and scales were the most frequent clinical signs. Histologically, a dermal infiltrate of small to medium-sized lymphocytes, occasionally extending to the subcutis, was always identified. Conversely, when present, epitheliotropism was generally mild. I

SUBMITTER: Albanese F 

PROVIDER: S-EPMC8778986 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature