Regulatory Role of Phospholipids in Hepatitis C Virus Replication and Protein Function.

ABSTRACT: Positive-strand RNA viruses such as hepatitis C virus (HCV) hijack key factors of lipid metabolism of infected cells and extensively modify intracellular membranes to support the viral lifecycle. While lipid metabolism plays key roles in viral particle assembly and maturation, viral RNA synthesis is closely linked to the remodeling of intracellular membranes. The formation of viral replication factories requires a number of interactions between virus proteins and host factors including lipids. The structure-function relationship of those proteins is influenced by their lipid environments and lipids that selectively modulate protein function. Here, we review our current understanding on the roles of phospholipids in HCV replication and of lipid-protein interactions in the structure-function

SUBMITTER: Bulankina AV 

PROVIDER: S-EPMC8779051 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature