Spatiotemporal Changes in Plasmodium vivax msp1₄₂ Haplotypes in Southern Mexico: From the Control to the Pre-Elimination Phase.

ABSTRACT: For 20 years, Plasmodium vivax has been the only prevalent malaria species in Mexico, and cases have declined significantly and continuously. Spatiotemporal genetic studies can be helpful for understanding parasite dynamics and developing strategies to weaken malaria transmission, thus facilitating the elimination of the parasite. The aim of the current contribution was to analyze P. vivax-infected blood samples from patients in southern Mexico during the control (1993-2007) and pre-elimination phases (2008-2011). Nucleotide and haplotype changes in the pvmsp1₄₂ fragment were evaluated over time. The majority of multiple genotype infections occurred in the 1990s, when the 198 single nucleotide sequences exhibited 57 segregating sites, 64 mutations, and

SUBMITTER: Flores-Alanis A 

PROVIDER: S-EPMC8779127 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature