Quercetin Liposomal Nanoformulation for Ischemia and Reperfusion Injury Treatment.

ABSTRACT: Ischemia and reperfusion injury (IRI) is a common complication caused by inflammation and oxidative stress resulting from liver surgery. Current therapeutic strategies do not present the desirable efficacy, and severe side effects can occur. To overcome these drawbacks, new therapeutic alternatives are necessary. Drug delivery nanosystems have been explored due to their capacity to improve the therapeutic index of conventional drugs. Within nanocarriers, liposomes are one of the most successful, with several formulations currently in the market. As improved therapeutic outcomes have been demonstrated by using liposomes as drug carriers, this nanosystem was used to deliver quercetin, a flavonoid with anti-inflammatory and antioxidant properties, in hepatic IRI treatment. In the present work

SUBMITTER: Ferreira-Silva M 

PROVIDER: S-EPMC8779145 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature