The Importance of Glycerophospholipid Production to the Mutualist Symbiosis of Trypanosomatids.

ABSTRACT: The symbiosis in trypanosomatids is a mutualistic relationship characterized by extensive metabolic exchanges between the bacterium and the protozoan. The symbiotic bacterium can complete host essential metabolic pathways, such as those for heme, amino acid, and vitamin production. Experimental assays indicate that the symbiont acquires phospholipids from the host trypanosomatid, especially phosphatidylcholine, which is often present in bacteria that have a close association with eukaryotic cells. In this work, an in-silico study was performed to find genes involved in the glycerophospholipid (GPL) production of Symbiont Harboring Trypanosomatids (SHTs) and their respective bacteria, also extending the search for trypanosomatids that naturally do not have symbionts. Results showed that mos

SUBMITTER: de Azevedo-Martins AC 

PROVIDER: S-EPMC8779180 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature