The <i>Campylobacter jejuni</i> Response Regulator and Cyclic-Di-GMP Binding CbrR Is a Novel Regulator of Flagellar Motility.

ABSTRACT: A leading cause of bacterial gastroenteritis, Campylobacter jejuni is also associated with broad sequelae, including extragastrointestinal conditions such as reactive arthritis and Guillain-Barré Syndrome (GBS). CbrR is a C. jejuni response regulator that is annotated as a diguanylate cyclase (DGC), an enzyme that catalyzes the synthesis of c-di-GMP, a universal bacterial second messenger, from GTP. In C. jejuni DRH212, we constructed an unmarked deletion mutant, cbrR^-, and complemented mutant, cbrR⁺. Motility assays indicated a hyper-motile phenotype associated with cbrR^-, whereas motility was deficient in cbrR⁺. The overexpression of CbrR in cbrR⁺ was accompanied by a reduction

SUBMITTER: Cox CA 

PROVIDER: S-EPMC8779298 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature