A Population of CD4⁺CD8⁺ Double-Positive T Cells Associated with Risk of Plasma Leakage in Dengue Viral Infection.

ABSTRACT: According to the WHO 2009 classification, dengue with warning signs is at the risk of developing severe form of dengue disease. One of the most important warning signs is plasma leakage, which can be a serious complication associated with higher morbidity and mortality. We report that the frequency of CD4⁺CD8⁺ double-positive (DP) T cells is significantly increased in patients at risk of developing plasma leakage. Transcriptomic analysis demonstrated that CD4⁺CD8⁺ DP cells were distinct from CD4⁺ Single Positive (SP) T cells but co-clustered with CD8⁺ SP cells, indicating a largely similar transcriptional profile. Twenty significant differentially expressed (DE) genes were identified between CD4⁺CD8⁺ DP

SUBMITTER: Yu ED 

PROVIDER: S-EPMC8779337 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature