In Silico and In Vitro Structure-Activity Relationship of Mastoparan and Its Analogs.

ABSTRACT: Antimicrobial peptides are an important class of therapeutic agent used against a wide range of pathogens such as Gram-negative and Gram-positive bacteria, fungi, and viruses. Mastoparan (MpVT) is an α-helix and amphipathic tetradecapeptide obtained from Vespa tropica venom. This peptide exhibits antibacterial activity. In this work, we investigate the effect of amino acid substitutions and deletion of the first three C-terminal residues on the structure-activity relationship. In this in silico study, the predicted structure of MpVT and its analog have characteristic features of linear cationic peptides rich in hydrophobic and basic amino acids without disulfide bonds. The secondary structure and the biological activity of six designed analogs are studied. The biological activity assays sh

SUBMITTER: Rungsa P 

PROVIDER: S-EPMC8779355 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature