Silica-Based Stimuli-Responsive Systems for Antitumor Drug Delivery and Controlled Release.

ABSTRACT: The administration of cytotoxic drugs in classical chemotherapy is frequently limited by water solubility, low plasmatic stability, and a myriad of secondary effects associated with their diffusion to healthy tissue. In this sense, novel pharmaceutical forms able to deliver selectively these drugs to the malign cells, and imposing a space-time precise control of their discharge, are needed. In the last two decades, silica nanoparticles have been proposed as safe vehicles for antitumor molecules due to their stability in physiological medium, high surface area and easy functionalization, and good biocompatibility. In this review, we focus on silica-based nanomedicines provided with specific mechanisms for intracellular drug release. According to silica nature (amorphous, mesostructured, and

SUBMITTER: Corma A 

PROVIDER: S-EPMC8779356 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature