Polymer Microparticles Prolong Delivery of the 15-PGDH Inhibitor SW033291.

ABSTRACT: As the prevalence of age-related fibrotic diseases continues to increase, novel antifibrotic therapies are emerging to address clinical needs. However, many novel therapeutics for managing chronic fibrosis are small-molecule drugs that require frequent dosing to attain effective concentrations. Although bolus parenteral administrations have become standard clinical practice, an extended delivery platform would achieve steady-state concentrations over a longer time period with fewer administrations. This study lays the foundation for the development of a sustained release platform for the delivery of (+)SW033291, a potent, small-molecule inhibitor of the 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme, which has previously demonstrated efficacy in a murine model of pulmonary fibrosis

SUBMITTER: Dogan AB 

PROVIDER: S-EPMC8779392 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature