Dissecting the Complexity of Early Heart Progenitor Cells.

ABSTRACT: Early heart development depends on the coordinated participation of heterogeneous cell sources. As pioneer work from Adriana C. Gittenberger-de Groot demonstrated, characterizing these distinct cell sources helps us to understand congenital heart defects. Despite decades of research on the segregation of lineages that form the primitive heart tube, we are far from understanding its full complexity. Currently, single-cell approaches are providing an unprecedented level of detail on cellular heterogeneity, offering new opportunities to decipher its functional role. In this review, we will focus on three key aspects of early heart morphogenesis: First, the segregation of myocardial and endocardial lineages, which yields an early lineage diversification in cardiac development; second, the sign

SUBMITTER: Sendra M 

PROVIDER: S-EPMC8779398 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature