Dataset Information
Synthesis of Novel (S)-3-(1-Aminoethyl)-8-pyrimidinyl-2-phenylisoquinolin-1(2H)-ones by Suzuki-Miyaura Coupling and Their Cell Toxicity Activities.
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ABSTRACT:
SUBMITTER: Choi OK
PROVIDER: S-EPMC8779526 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Synthesis of Novel (<i>S</i>)-3-(1-Aminoethyl)-8-pyrimidinyl-2-phenylisoquinolin-1(2<i>H</i>)-ones by Suzuki-Miyaura Coupling and Their Cell Toxicity Activities.
Pharmaceuticals (Basel, Switzerland) 20220104 1
A series of (<i>S</i>)-3-(1-aminoethyl)-8-pyrimidinyl-2-phenylisoquinoline-1(2<i>H</i>)-ones <b>3a</b>-<b>3k</b> was synthesized in 40-98% yield through Suzuki-Miyaura coupling using Pd(PPh<sub>3</sub>)<sub>2</sub>Cl<sub>2</sub>, Sphos, and K<sub>2</sub>CO<sub>3</sub> in THF/H<sub>2</sub>O mixed solvent. All newly synthesized compounds were evaluated for cell viability (IC<sub>50</sub>) against MDA-MB-231, HeLa, and HepG2 cells. The antitumor activities of <b>3a</b>-<b>3k</b> were improved when ...[more]