Ischemia and no obstructive coronary arteries in patients with stable ischemic heart disease.

ABSTRACT: A large proportion of patients with suspected obstructive coronary artery disease (CAD) is found to have ischemia with no obstructive coronary artery disease (INOCA). Based on current evidence, these patients are at increased risk of adverse cardiovascular events, even though they have no obstructive CAD. Importantly, INOCA is associated with recurrent clinical presentations with chest pain, impaired functional capacity, reduced health-related quality of life, and high healthcare costs. Underlying coronary microvascular dysfunction (CMD), through endothelium-dependent and independent mechanisms contribute to these adverse outcomes in INOCA. While non-invasive and invasive diagnostic testing has typically focused on identification of obstructive CAD in symptomatic patients, functional testi

SUBMITTER: Mehta PK 

PROVIDER: S-EPMC8779638 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature