Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells.

ABSTRACT: After peripheral nerve injury, mature Schwann cells (SCs) de-differentiate and undergo cell reprogramming to convert into a specialized cell repair phenotype that promotes nerve regeneration. Reprogramming of SCs into the repair phenotype is tightly controlled at the genome level and includes downregulation of pro-myelinating genes and activation of nerve repair-associated genes. Nerve injuries induce not only biochemical but also mechanical changes in the tissue architecture which impact SCs. Recently, we showed that SCs mechanically sense the stiffness of the extracellular matrix and that SC mechanosensitivity modulates their morphology and migratory behavior. Here, we explore the expression levels of key transcription factors and myelin-associated genes in SCs, and the outgrowth of prim

SUBMITTER: Rosso G 

PROVIDER: S-EPMC8780053 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature