Area light source-triggered latent angiogenic molecular mechanisms intensify therapeutic efficacy of adult stem cells.

ABSTRACT: Light-based therapy such as photobiomodulation (PBM) reportedly produces beneficial physiological effects in cells and tissues. However, most reports have focused on the immediate and instant effects of light. Considering the physiological effects of natural light exposure in living organisms, the latent reaction period after irradiation should be deliberated. In contrast to previous reports, we examined the latent reaction period after light exposure with optimized irradiating parameters and validated novel therapeutic molecular mechanisms for the first time. we demonstrated an organic light-emitting diode (OLED)-based PBM (OPBM) strategy that enhances the angiogenic efficacy of human adipose-derived stem cells (hADSCs) via direct irradiation with red OLEDs of optimized wavelength, voltag

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC8780080 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature