Reduced Efficacy of Low-dose Topical Steroids in Dry Eye Disease Associated With Graft-versus-Host Disease.

ABSTRACT:

Purpose

To compare the response of dry eye disease (DED) to treatment with topical steroid in patients with and without graft-vs-host disease (GVHD).

Design

Post hoc analysis of a double-masked, randomized clinical trial.

Methods

This single-center study included 42 patients with moderate-to-severe DED associated with (n = 21) or without (n = 21) chronic GVHD. In each group, patients received either loteprednol etabonate 0.5% ophthalmic suspension or artificial tears twice daily for 4 weeks. Clinical data, including Ocular Surface Disease Index (OSDI) questionnaire, corneal fluorescein staining (CFS), conjunctival lissamine green staining, tear break-up time (TBUT), and Schirmer test, were evaluated before and after treatment.

Results

There were no significant

SUBMITTER: Yin J 

PROVIDER: S-EPMC8780105 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature