Prenatal PM_2.5 Exposure in Relation to Maternal and Newborn Telomere Length at Delivery.

ABSTRACT: Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM_2.5) is a ubiquitous air pollutant that is increasingly threatening the health of adults and children worldwide. One health impact of elevated PM_2.5 exposure is alterations in telomere length (TL)-protective caps on chromosome ends that shorten with each cell division. Few analyses involve prenatal PM_2.5 exposure, and paired maternal and cord TL measurements. Here, we analyzed the association between average and trimester-specific prenatal PM_2.5 exposure, and maternal and newborn relative leukocyte TL measured at birth among 193 mothers and their newborns enrolled in a New-York-City-based birth cohort. Results indicated an overall negative relationship between prenatal PM_2.

SUBMITTER: Durham T 

PROVIDER: S-EPMC8780107 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature