The Effect of Circulating Zinc, Selenium, Copper and Vitamin K₁ on COVID-19 Outcomes: A Mendelian Randomization Study.

ABSTRACT: Background & Aims: Previous results from observational, interventional studies and in vitro experiments suggest that certain micronutrients possess anti-viral and immunomodulatory activities. In particular, it has been hypothesized that zinc, selenium, copper and vitamin K₁ have strong potential for prophylaxis and treatment of COVID-19. We aimed to test whether genetically predicted Zn, Se, Cu or vitamin K₁ levels have a causal effect on COVID-19 related outcomes, including risk of infection, hospitalization and critical illness. Methods: We employed a two-sample Mendelian Randomization (MR) analysis. Our genetic variants derived from European-ancestry GWAS reflected circulating levels of Zn, Cu, Se in red blood cells as well as Se and vitamin K_1</

SUBMITTER: Sobczyk MK 

PROVIDER: S-EPMC8780111 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature