Regional Brain Analysis of Modified Amino Acids and Dipeptides during the Sleep/Wake Cycle.

ABSTRACT: Sleep is a state in which important restorative and anabolic processes occur. Understanding changes of these metabolic processes during the circadian rhythm in the brain is crucial to elucidate neurophysiological mechanisms important for sleep function. Investigation of amino acid modifications and dipeptides has recently emerged as a valuable approach in the metabolic profiling of the central nervous system. Nonetheless, very little is known about the effects of sleep on the brain levels of amino acid analogues. In the present study, we examined brain regional sleep-induced alterations selective for modified amino acids and dipeptides using Ultra-high performance liquid chromatography-MS/MS (UHPLC-MS/MS) based metabolomics. Our approach enabled the detection and identification of numerous

SUBMITTER: Vallianatou T 

PROVIDER: S-EPMC8780251 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature