Double-Layer Fatty Acid Nanoparticles as a Multiplatform for Diagnostics and Therapy.

ABSTRACT: Today, public health is one of the most important challenges in society. Cancer is the leading cause of death, so early diagnosis and localized treatments that minimize side effects are a priority. Magnetic nanoparticles have shown great potential as magnetic resonance imaging contrast agents, detection tags for in vitro biosensing, and mediators of heating in magnetic hyperthermia. One of the critical characteristics of nanoparticles to adjust to the biomedical needs of each application is their polymeric coating. Fatty acid coatings are known to contribute to colloidal stability and good surface crystalline quality. While monolayer coatings make the particles hydrophobic, a fatty acid double-layer renders them hydrophilic, and therefore suitable for use in body fluids. In addition, they

SUBMITTER: Salvador M 

PROVIDER: S-EPMC8780348 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature