Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children.

ABSTRACT: The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults. The objectives of this study were: (i) to provide a comprehensive review of the age-dependent anatomical and physiological changes in pediatric skin, and (ii) to construct and evaluate an age-dependent pediatric dermal absorption model. A comprehensive review was conducted to gather data quantifying the differences in the anatomy and physiology of child and adult skin. Maturation functions were developed for model parameters that were found to be age-dependent. A pediatric dermal absorption model was constructed by updating a MoBi implementation of the Dancik et al. 2013 skin permeation model with these maturation functions. Using

SUBMITTER: Yun YE 

PROVIDER: S-EPMC8780349 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature