Naloxegol and Postoperative Urinary Retention: A Randomized Trial.

ABSTRACT: Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. patients given naloxegol have lower residual bladder urine volume than those given placebo. 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. 67 were randomized to

SUBMITTER: Turan A 

PROVIDER: S-EPMC8780376 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature