Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing.

ABSTRACT: Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box-Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration

SUBMITTER: Saddik MS 

PROVIDER: S-EPMC8780377 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature