Adsorption and Sustained Delivery of Small Molecules from Nanosilicate Hydrogel Composites.

ABSTRACT: Two-dimensional nanosilicate particles (NS) have shown promise for the prolonged release of small-molecule therapeutics while minimizing burst release. When incorporated in a hydrogel, the high surface area and charge of NS enable electrostatic adsorption and/or intercalation of therapeutics, providing a lever to localize and control release. However, little is known about the physio-chemical interplay between the hydrogel, NS, and encapsulated small molecules. Here, we fabricated polyethylene glycol (PEG)-NS hydrogels for the release of model small molecules such as acridine orange (AO). We then elucidated the effect of NS concentration, NS/AO incubation time, and the ability of NS to freely associate with AO on hydrogel properties and AO release profiles. Overall, NS incorporation increa

SUBMITTER: Stealey S 

PROVIDER: S-EPMC8780425 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature