Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway.

ABSTRACT:

Background

Silencing of the periostin gene (POSTN) can inhibit the biological process of several different cancers, and this inhibition may be related to down-regulation of PI3K/AKT signaling. However, the effect of POSTN on the progression, proliferation, and invasion of osteosarcoma (OS) remain unclear.

Methods

We used the Gene Expression Omnibus (GEO) database to screen datasets on in situ OS and lung metastases to identify core genes and potential pathways. We used additional bioinformatics tools to identify protein-protein interactions (PPIs) and gene networks, and selected the top seven genes whose expression had the strongest correlations with other genes.

Results

The results indicated that POSTN was a major hub gene. Subsequent analysis of gene expression prof

SUBMITTER: Xu C 

PROVIDER: S-EPMC8780812 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature