Characterization of Possible α-Glucosidase Inhibitors from Trigonella stellata Extract Using LC-MS and In Silico Molecular Docking.

ABSTRACT: The current study accentuates the significance of performing the multiplex approach of LC-HRESIMS, biological activity, and docking studies in drug discovery, taking into consideration a review of the literature. In this regard, the investigation of antioxidant and cytotoxic activities of Trigonella stellata collected from the Egyptian desert revealed a significant antioxidant capacity using DPPH with IC₅₀ = 656.9 µg/mL and a moderate cytotoxicity against HepG2, MCF7, and CACO2, with IC₅₀ values of 53.3, 48.3, and 55.8 µg/mL, respectively. The evaluation of total phenolic and flavonoid contents resulted in 32.8 mg GAE/g calculated as gallic acid equivalent and 5.6 mg RE/g calculated as rutin equivalent, respectively. Chemical profiling of T. stellata ext

SUBMITTER: Elwekeel A 

PROVIDER: S-EPMC8780848 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature