Assessment of human adipose-derived stem cell on surface-modified silicone implant to reduce capsular contracture formation.

ABSTRACT: Medical devices made from poly(dimethylsiloxane) (PDMS)-based silicone implants have been broadly used owing to their inert properties, biocompatibility, and low toxicity. However, long-term implantation is usually associated with complications, such as capsular contracture due to excessive local inflammatory response, subsequently requiring implant removal. Therefore, modification of the silicone surface to reduce a risk of capsular contracture has attracted increasing attention. Human adipose-derived stem cells (hASCs) are known to provide potentially therapeutic applications for tissue engineering, regenerative medicine, and reconstructive surgery. Herein, hASCs coating on a PDMS (hASC-PDMS) or itaconic acid (IA)-conjugated PDMS (hASC-IA-PDMS) surface is examined to determine its biocom

SUBMITTER: Sutthiwanjampa C 

PROVIDER: S-EPMC8780897 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature