Functional genetic variants in complement component 7 confer susceptibility to gastric cancer.

ABSTRACT:

Background

Complement system plays an important role in innate immunity which involved in the changes tumor immune microenvironment by mediating the inflammatory response. This study aims to explore the relationship between complement component 7 (C7) polymorphisms and the risk of gastric cancer (GC).

Materials and methods

All selected SNPs of C7 were genotyped in 471 patients and 471 controls using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional Logistic regression to analyze the relationship between each genotype and the genetic susceptibility to gastric cancer. The level of C7 expression in GC was analyzed by Gene Expression

SUBMITTER: Wang S 

PROVIDER: S-EPMC8781313 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature