Discovering the key genes and important DNA methylation regions in breast cancer.

ABSTRACT:

Background

Breast cancer is the malignant tumor with the highest incidence in women. DNA methylation has an important effect on breast cancer, but the effect of abnormal DNA methylation on gene expression in breast cancer is still unclear. Therefore, it is very important to find therapeutic targets related to DNA methylation.

Results

In this work, we calculated the DNA methylation distribution and gene expression level in cancer and para-cancerous tissues for breast cancer samples. We found that DNA methylation in key regions is closely related to gene expression by analyzing the relationship between the distribution characteristics of DNA methylation in different regions and the change of gene expression level. Finally, the 18 key genes (17 tumor suppressor genes and 1 onco

SUBMITTER: Cao YN 

PROVIDER: S-EPMC8781361 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature