Vitamin C improves microvascular reactivity and peripheral tissue perfusion in septic shock patients.

ABSTRACT:

Background

Vitamin C has potential protective effects through antioxidant and anti-inflammatory properties. However, the effect of vitamin C supplementation on microvascular function and peripheral tissue perfusion in human sepsis remains unknown. We aimed to determine vitamin C effect on microvascular endothelial dysfunction and peripheral tissue perfusion in septic shock patients.

Methods

Patients with septic shock were prospectively included after initial resuscitation. Bedside peripheral tissue perfusion and skin microvascular reactivity in response to acetylcholine iontophoresis in the forearm area were measured before and 1 h after intravenous vitamin C supplementation (40 mg/kg). Norepinephrine dose was not modified during the studied period.

Results

We include

SUBMITTER: Lavillegrand JR 

PROVIDER: S-EPMC8781452 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature