Stingray Venom Proteins: Mechanisms of Action Revealed Using a Novel Network Pharmacology Approach.

ABSTRACT: Animal venoms offer a valuable source of potent new drug leads, but their mechanisms of action are largely unknown. We therefore developed a novel network pharmacology approach based on multi-omics functional data integration to predict how stingray venom disrupts the physiological systems of target animals. We integrated 10 million transcripts from five stingray venom transcriptomes and 848,640 records from three high-content venom bioactivity datasets into a large functional data network. The network featured 216 signaling pathways, 29 of which were shared and targeted by 70 transcripts and 70 bioactivity hits. The network revealed clusters for single envenomation outcomes, such as pain, cardiotoxicity and hemorrhage. We carried out a detailed analysis of the pain cluster representing a

SUBMITTER: Kirchhoff KN 

PROVIDER: S-EPMC8781517 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature