Acute Pneumonia Caused by Clinically Isolated Legionella pneumophila Sg 1, ST 62: Host Responses and Pathologies in Mice.
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ABSTRACT:
SUBMITTER: Trousil J
PROVIDER: S-EPMC8781576 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
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Acute Pneumonia Caused by Clinically Isolated <i>Legionella pneumophila</i> Sg 1, ST 62: Host Responses and Pathologies in Mice.
Trousil Jiří J Frgelecová Lucia L Kubíčková Pavla P Řeháková Kristína K Drašar Vladimír V Matějková Jana J Štěpánek Petr P Pavliš Oto O
Microorganisms 20220114 1
Legionnaires' disease is a severe form of lung infection caused by bacteria belonging to the genus <i>Legionella</i>. The disease severity depends on both host immunity and <i>L. pneumophila</i> virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of <i>L. pneumophila</i> serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 10<sup>4</sup> and 10<sup>6</sup> CFU, and their i ...[more]
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