Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis.

ABSTRACT:

Background

Epigenetic regulation relies on the activity of enzymes that use sentinel metabolites as cofactors to modify DNA or histone proteins. Thus, fluctuations in cellular metabolite levels have been reported to affect chromatin modifications. However, whether epigenetic modifiers also affect the levels of these metabolites and thereby impinge on downstream metabolic pathways remains largely unknown. Here, we tested this notion by investigating the function of N-alpha-acetyltransferase 40 (NAA40), the enzyme responsible for N-terminal acetylation of histones H2A and H4, which has been previously implicated with metabolic-associated conditions such as age-dependent hepatic steatosis and calorie-restriction-mediated longevity.

Results

Using metabolomic and lipidomic approa

SUBMITTER: Charidemou E 

PROVIDER: S-EPMC8781613 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature