Sequence and Structure-Based Analyses of Human Ankyrin Repeats.

ABSTRACT: Ankyrin is one of the most abundant protein repeat families found across all forms of life. It is found in a variety of multi-domain and single domain proteins in humans with diverse number of repeating units. They are observed to occur in several functionally diverse proteins, such as transcriptional initiators, cell cycle regulators, cytoskeletal organizers, ion transporters, signal transducers, developmental regulators, and toxins, and, consequently, defects in ankyrin repeat proteins have been associated with a number of human diseases. In this study, we have classified the human ankyrin proteins into clusters based on the sequence similarity in their ankyrin repeat domains. We analyzed the amino acid compositional bias and consensus ankyrin motif sequence of the clusters to understand

SUBMITTER: Chakrabarty B 

PROVIDER: S-EPMC8781854 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature