A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages.

ABSTRACT: Breast cancer (BC) as a leading cause of cancer death among women, exhibits a wide range of genetic heterogeneity in affected individuals. Satisfactory management of BC depends on early diagnosis and proper monitoring of patients' response to therapy. In this study, we aimed to assess the relation between the expression patterns of blood-based microRNAs (miRNAs) with demographic characteristics of the patients with BC in an attempt to find novel diagnostic markers for BC with acceptable precision in clinical applications. To this end, we performed comprehensive statistical analysis of the data of the Cancer Genome Atlas (TCGA) database and the blood miRNome dataset (GSE31309). As a result, 21 miRNAs were selected for experimental verification by quantitative RT-PCR on blood samples of 70 B

SUBMITTER: Sadeghi H 

PROVIDER: S-EPMC8782186 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature