Dataset Information

Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders.

ABSTRACT:

Introduction

Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa.

Methods

Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, as well as manual searches in relevant reviews and included articles. Analytical studies from Africa evaluating the association between HCC development and HBV, HCV, and HDV were included. Relevant studies were selected, data extracted, and the risk of bias assessed independently by at least 2 investigators. The association was estimated using odds ratios (OR) and their 95% confidence interval (95% CI) determined by a random-effects model. Sources of heterogeneity were determined by subgroup analyses.

Results

A total of 36 case-control studies were included. With controls having non-hepatic disease, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBeAg (OR = 19.9; 95% CI = [3.7-105.2]), HBsAg (OR = 9.9; 95%) CI = [6.2-15.6]) and DNA (OR = 8.9; 95% CI = [5.9-13.4]); HCV (Anti-HCV (OR = 9.4; 95% CI = [6.3-14.0]) and RNA (OR = 16.5; 95% CI = [7.8-34.6]); HDV (Anti-VHD, (OR = 25.8; 95% CI = [5.9-112.2]); and HBV/HCV coinfections (HBV DNA/HCV RNA (OR = 22.5; 95% CI = [1.3-387.8]). With apparently healthy controls, the overall results suggested a significantly increased risk of HCC in patients with HBV (HBsAg, (OR = 8.9; 95% CI = [6.0-13.0]); HCV (Anti-HCV, (OR = 7.7; 95% CI = [5.6-10.6]); and HBV/HCV coinfections (HBsAg/Anti-HCV (OR = 7.8; 95% CI = [4.4-13.6]) Substantial heterogeneity and the absence of publication bias were recorded for these results.

Conclusions

In Africa, HBV/HCV coinfections and HBV, HCV, and HDV infections are associated with an increased risk of developing HCC. The implementation of large-scale longitudinal and prospective studies including healthy participants to search for early biomarkers of the risk of progression to HCC is urgently needed.

SUBMITTER: Mbaga DS

PROVIDER: S-EPMC8782350 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders.

Mbaga Donatien Serge DS Kenmoe Sebastien S Kengne-Ndé Cyprien C Ebogo-Belobo Jean Thierry JT Mahamat Gadji G Foe-Essomba Joseph Rodrigue JR Amougou-Atsama Marie M Tchatchouang Serges S Nyebe Inès I Feudjio Alfloditte Flore AF Kame-Ngasse Ginette Irma GI Magoudjou-Pekam Jeannette Nina JN Fokou Lorraine K M LKM Meta-Djomsi Dowbiss D Maïdadi-Foudi Martin M Touangnou-Chamda Sabine Aimee SA Daha-Tchoffo Audrey Gaelle AG Selly-Ngaloumo Abdel Aziz AA Nayang-Mundo Rachel Audrey RA Yéngué Jacqueline Félicité JF Taya-Fokou Jean Bosco JB Kenfack-Momo Raoul R Atembeh Noura Efietngab E Demeni Emoh Cynthia Paola CP Tazokong Hervé Raoul HR Bowo-Ngandji Arnol A Sake Carole Stéphanie CS Atenguena Okobalemba Etienne E Njiki Bikoi Jacky J Njouom Richard R Riwom Essama Sara Honorine SH

PloS one 20220121 1

<h4>Introduction</h4>Africa denotes unique facies for hepatocellular carcinoma (HCC) characterized by a conjunction of low sensitization, restricted access to diagnosis and treatment and associated with the highest incidence and mortality in the world. We investigated whether hepatitis B (HBV), C (HCV) and D (VHD) viruses were etiological agents of HCC in Africa.<h4>Methods</h4>Relevant articles were searched in PubMed, Web of Science, African Index Medicus, and African Journal Online databases, ...[more]

PMID: 35061846

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Dataset Information

Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders.

Introduction

Methods

Results

Conclusions

Publications

Hepatitis B, C and D virus infections and risk of hepatocellular carcinoma in Africa: A meta-analysis including sensitivity analyses for studies comparable for confounders.

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