Application of the Taguchi method to explore a robust condition of tumor-treating field treatment.

ABSTRACT: Tumor-treating fields have potential as minimally invasive cancer treatment. This study aimed to explore the optimum tumor-treating field conditions that minimize unpredicted variations in therapeutic outcomes resulting from differences in cell size and electrical properties. The electric field concentration that induces a dielectrophoretic force near the division plane of a mitotic cell was calculated by finite element analysis for 144 cases, based on different combinations of six noise factors associated with cells and four controllable factors including frequency, as determined by the Taguchi method. Changing the frequency from 200 to 400 kHz strongly increased robustness in producing a dielectrophoretic force, irrespective of noise factors. However, this frequency change reduced the fo

SUBMITTER: Kurata K 

PROVIDER: S-EPMC8782397 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature