Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors.
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ABSTRACT:
SUBMITTER: Datta R
PROVIDER: S-EPMC8782446 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
Interactions with stromal cells promote a more oxidized cancer cell redox state in pancreatic tumors.
Datta Rupsa R Sivanand Sharanya S Lau Allison N AN Florek Logan V LV Barbeau Anna M AM Wyckoff Jeffrey J Skala Melissa C MC Vander Heiden Matthew G MG
Science advances 20220121 3
Access to electron acceptors supports oxidized biomass synthesis and can be limiting for cancer cell proliferation, but how cancer cells overcome this limitation in tumors is incompletely understood. Nontransformed cells in tumors can help cancer cells overcome metabolic limitations, particularly in pancreatic cancer, where pancreatic stellate cells (PSCs) promote cancer cell proliferation and tumor growth. However, whether PSCs affect the redox state of cancer cells is not known. By taking adva ...[more]
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