Complexity and variability analyses of motor activity distinguish mood states in bipolar disorder.

ABSTRACT: Changes in motor activity are core symptoms of mood episodes in bipolar disorder. The manic state is characterized by increased variance, augmented complexity and irregular circadian rhythmicity when compared to healthy controls. No previous studies have compared mania to euthymia intra-individually in motor activity. The aim of this study was to characterize differences in motor activity when comparing manic patients to their euthymic selves. Motor activity was collected from 16 bipolar inpatients in mania and remission. 24-h recordings and 2-h time series in the morning and evening were analyzed for mean activity, variability and complexity. Lastly, the recordings were analyzed with the similarity graph algorithm and graph theory concepts such as edges, bridges, connected components and

SUBMITTER: Jakobsen P 

PROVIDER: S-EPMC8782466 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature