Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19.

ABSTRACT: COVID-19 displays diverse disease severities and symptoms including acute systemic inflammation and hypercytokinemia, with subsequent dysregulation of immune cells. Bacterial superinfections in COVID-19 can further complicate the disease course and are associated with increased mortality. However, there is limited understanding of how SARS-CoV-2 pathogenesis and hypercytokinemia impede the innate immune function against bacterial superinfections. We assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery-phase. We show that a severe hypercytokinemia status in COVID-19 patients correlates with the development of bacterial superinfections. Neutr

SUBMITTER: Mairpady Shambat S 

PROVIDER: S-EPMC8782468 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature