Androgen Receptor Regulates CD44 Expression in Bladder Cancer.

ABSTRACT: The androgen receptor (AR) is important in the development of both experimental and human bladder cancer. However, the role of AR in bladder cancer growth and progression is less clear, with literature indicating that more advanced stage and grade disease are associated with reduced AR expression. To determine the mechanisms underlying these relationships, we profiled AR-expressing human bladder cancer cells by AR chromatin immunoprecipitation sequencing and complementary transcriptomic approaches in response to in vitro stimulation by the synthetic androgen R1881. In vivo functional genomics consisting of pooled shRNA or pooled open reading frame libraries was employed to evaluate 97 genes that recapitulate the direction of expression associated with androgen stimulation. In

SUBMITTER: Sottnik JL 

PROVIDER: S-EPMC8782536 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature