Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway.

ABSTRACT:

Rationale

Cardiac aging is an important contributing factor for heart failure, which affects a large population but remains poorly understood.

Objective

The purpose of this study is to investigate whether Klotho plays a role in cardiac aging.

Methods and results

Heart function declined in old mice (24 months), as evidenced by decreases in fractional shortening, ejection fraction, and cardiac output. Heart size and weight, cardiomyocyte size, and cardiac fibrosis were increased in old mice, indicating that aging causes cardiac hypertrophy and remodeling. Circulating Klotho levels were dramatically decreased in old mice, which prompted us to investigate whether the Klotho decline may cause heart aging. We found that Klotho gene mutation (KL-/-) largely decreased

SUBMITTER: Chen K 

PROVIDER: S-EPMC8782577 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature