FGF-23 (Fibroblast Growth Factor-23) and Cardiorenal Interactions.

ABSTRACT:

Background

Animal models implicate FGF-23 (fibroblast growth factor-23) as a direct contributor to adverse cardiorenal interactions such as sodium avidity, diuretic resistance, and neurohormonal activation, but this has not been conclusively demonstrated in humans. Therefore, we aimed to evaluate whether FGF-23 is associated with parameters of cardiorenal dysfunction in humans with heart failure, independent of confounding factors.

Methods

One hundred ninety-nine outpatients with heart failure undergoing diuretic treatment at the Yale Transitional Care Center were enrolled and underwent blood collection, and urine sampling before and after diuretics.

Results

FGF-23 was associated with several metrics of disease severity such as higher home loop diuretic dose and NT-pr

SUBMITTER: Ivey-Miranda JB 

PROVIDER: S-EPMC8782627 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature